Product Intro:
Zoladex LA 10.8mg is a subcutaneous implant injection containing Goserelin Acetate, a gonadotropin-releasing hormone agonist (GnRH agonist). It is designed for extended hormone suppression, with one dose effective for 3 months.
Uses:
Zoladex LA 10.8mg is used for:
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Prostate cancer (hormone-sensitive, advanced or localized)
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Breast cancer in premenopausal women (hormone-receptor positive)
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Endometriosis (long-term management)
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Uterine fibroids (to reduce fibroid size before surgery)
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Management of abnormal uterine bleeding
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Fertility treatment protocols
Storage Instructions:
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Store below 25°C
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Protect from light and moisture
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Do not freeze
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Keep out of reach of children
How it Works (Mechanism of Action):
Goserelin Acetate acts as a GnRH agonist. Initially, it causes a surge in luteinizing hormone (LH) and follicle-stimulating hormone (FSH), which increases sex hormone levels. Continued use leads to receptor downregulation and inhibition of LH/FSH release, drastically reducing estrogen and testosterone levels—this helps in shrinking hormone-sensitive tumors or tissues.
Side Effects:
Common Side Effects:
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Hot flashes
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Night sweats
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Headache
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Mood swings or depression
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Libido loss
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Vaginal dryness or erectile dysfunction
Severe Side Effects:
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Osteoporosis or bone thinning (with prolonged use)
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Tumor flare (temporary worsening of symptoms)
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Injection site reactions
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Cardiovascular issues (rare)
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Changes in blood sugar or cholesterol levels
Dosage (Typical Recommended Dose):
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10.8mg administered once every 12 weeks (3 months)
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Dosage may vary based on indication and patient response
Method of Administration:
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Administered subcutaneously into the anterior abdominal wall
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Must be given by a trained healthcare professional
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Single-use prefilled syringe containing a biodegradable implant
Precautions:
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Not recommended during pregnancy or lactation
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Regular bone density monitoring is advised for long-term therapy
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Caution in diabetic or cardiovascular patients
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May cause temporary increase in symptoms due to tumor flare
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Use with caution in patients with depression or osteoporosis history
Drug Interactions:
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May interact with hormone therapies, anti-androgens, or fertility treatments
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No major interactions with antibiotics or common painkillers
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Always inform your doctor about all medications and supplements
Allergies:
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Contraindicated in patients allergic to Goserelin or similar GnRH analogs
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Watch for allergic reactions such as hives, rash, swelling, or difficulty breathing
Overdose Information:
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Overdose is rare due to the long-acting implant formulation
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Symptoms may include prolonged hormone suppression effects
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Seek immediate medical attention if overdose is suspected
Missed Dose Instructions:
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If a scheduled injection is missed, contact your healthcare provider immediately
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Timely re-administration is crucial for continuous therapy
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Do not self-administer or double dose
Additional Notes:
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Zoladex LA 10.8mg is often used in combination with anti-androgens initially to prevent tumor flare in prostate cancer
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Bone health support (calcium, vitamin D) is recommended
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Inform your doctor about any mood changes or unusual symptoms during treatment
