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Palborest 125mg - Palbociclib Tablets

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Palborest 125mg - Palbociclib Tablets

Palborest 125mg is a targeted oral cancer therapy used to treat hormone receptor-positive, HER2-negative breast cancer. It works by selectively inhibiting proteins that promote cancer cell growth, thereby helping control the progression of the disease.

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Description Product Details
General Information:
Generic Name: Palbociclib
Brand Name: Palborest 125mg
Packing: Bottle of 21 tablets
Strength: 125 mg
Manufacturer: [Insert Manufacturer Name]
Form: Oral tablets
Category: Anti-cancer drug, CDK4/6 inhibitor
Product Introduction:
Palborest 125mg contains Palbociclib, a cyclin-dependent kinase (CDK) 4/6 inhibitor. It is used as part of a combination therapy with hormone-based medications for the treatment of advanced or metastatic breast cancer. This therapy helps slow tumor growth and improve patient outcomes.
Uses:
Palborest 125mg is used to treat:
  1. HR-positive, HER2-negative advanced breast cancer (in postmenopausal women and men)
  2. Used in combination with Letrozole as first-line treatment
  3. Used with Fulvestrant in patients with disease progression after hormone therapy
  4. Helps delay disease progression
  5. Improves overall survival and progression-free survival in advanced breast cancer
  6. May be used in both pre- and postmenopausal patients with hormone therapy
Storage Instructions:
  1. Store at room temperature (20°C – 25°C)
  2. Keep the bottle tightly closed and protect from moisture and light
  3. Keep out of reach of children
  4. Do not use after the expiration date
How It Works (Mechanism of Action):
Palbociclib inhibits CDK4 and CDK6, two enzymes essential for cell cycle progression from the G1 to S phase. By blocking these proteins, the medication stops cancer cells from dividing and growing, ultimately leading to cell cycle arrest and reduced tumor proliferation.
Side Effects:
Common side effects:
  1. Neutropenia (low white blood cell count)
  2. Fatigue
  3. Nausea
  4. Diarrhea or constipation
  5. Mouth sores (stomatitis)
  6. Hair thinning or loss
Severe side effects:
  1. Febrile neutropenia (infection with low WBC)
  2. Liver function abnormalities
  3. Pulmonary embolism (rare)
  4. Severe infections
  5. Bleeding or bruising
Dosage (Typical Recommended Dose):
  1. 125 mg orally once daily for 21 consecutive days, followed by 7 days off (28-day cycle)
  2. Used in combination with an aromatase inhibitor or Fulvestrant
  3. Dose adjustments may be required based on blood counts and side effects
Method of Administration:
  1. Take orally with food to improve absorption
  2. Swallow whole with water – do not crush, chew, or split the tablet
  3. Take the dose at the same time each day
  4. If vomiting occurs after taking, do not retake the dose that day
Precautions:
  1. Regular blood tests are required to monitor WBC counts
  2. Avoid grapefruit or grapefruit juice
  3. Use effective contraception during and after treatment
  4. Not recommended during pregnancy or breastfeeding
  5. Caution in patients with liver or kidney impairment
  6. Monitor for signs of infection, bleeding, or lung symptoms
Drug Interactions:
  1. Avoid CYP3A inhibitors and inducers (e.g., ketoconazole, rifampin)
  2. Avoid St. John’s Wort
  3. May interact with antibiotics, antifungals, and certain antivirals
  4. Inform your doctor about all medicines and supplements you are taking
Allergies:
  1. Rare allergic reactions may occur – signs include rash, itching, swelling, dizziness, or trouble breathing
  2. Discontinue and seek immediate medical help if allergic reactions are noticed
Overdose Information:
  1. Symptoms: Extreme fatigue, infections, easy bruising/bleeding, or other serious side effects
  2. Seek emergency medical attention
  3. No specific antidote; treatment is supportive and symptomatic
Missed Dose Instructions:
  1. If a dose is missed, skip the missed dose and take the next one at the regular time
  2. Do not double the dose to make up for a missed dose
  3. Maintain a strict daily dosing schedule for best outcomes
Additional Notes:
  1. Regular complete blood counts (CBCs) are essential, especially during the first two cycles
  2. Palbociclib is an oral chemotherapy—handle tablets with care and wash hands after handling
  3. Patients should report any fever, cough, shortness of breath, or unusual fatigue
  4. Supportive treatments such as growth factors may be used to manage neutropenia
  5. Diet and lifestyle support can help minimize GI side effects

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