Product Introduction:
Bdfoie 4mg is a prescription anti-cancer drug that contains the active ingredient Lenvatinib, a multi-kinase inhibitor. It is widely used as a part of systemic therapy in advanced-stage cancers such as differentiated thyroid cancer, hepatocellular carcinoma, and renal cell carcinoma. Manufactured to meet oncological treatment standards, it is a valuable part of modern targeted cancer therapy.
Uses:
Bdfoie 4mg is used in the treatment of:
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Differentiated Thyroid Cancer (DTC) – especially when radioactive iodine therapy is ineffective.
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Hepatocellular Carcinoma (HCC) – as first-line systemic therapy in liver cancer.
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Renal Cell Carcinoma (RCC) – used in combination with other drugs such as pembrolizumab.
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Endometrial Carcinoma – in combination with immune checkpoint inhibitors.
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Solid Tumors (off-label) – under clinical supervision or in specific cases.
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Medullary Thyroid Carcinoma – selectively used under trial or physician-directed cases.
Storage Instructions:
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Store at a temperature between 20–25°C.
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Keep in a dry place away from moisture and heat.
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Do not remove from blister until ready to use.
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Keep out of reach of children and pets.
How It Works (Mechanism of Action):
Lenvatinib is a multi-targeted tyrosine kinase inhibitor (TKI). It blocks the activity of several enzymes (including VEGFR1-3, FGFR1-4, PDGFRα, KIT, and RET) involved in tumor cell growth, angiogenesis (formation of new blood vessels), and cancer progression. By inhibiting these pathways, it starves the tumor of blood supply and slows its growth.
Side Effects:
Common side effects:
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Hypertension (high blood pressure)
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Fatigue
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Diarrhea
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Decreased appetite
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Weight loss
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Joint or muscle pain
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Nausea or vomiting
Serious side effects:
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Proteinuria (protein in urine)
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Heart problems (e.g., heart failure, QT prolongation)
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Liver toxicity
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Kidney dysfunction
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Gastrointestinal perforation or bleeding
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Blood clots or embolism
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Posterior Reversible Encephalopathy Syndrome (PRES) – rare but serious
Dosage (Typical Recommended Dose):
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The typical adult starting dose is 8 mg or 12 mg once daily, depending on cancer type and body weight.
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For example, in HCC, the dose may be 8 mg daily for patients <60 kg or 12 mg for those ≥60 kg.
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Dosage adjustments are made based on side effects and tolerability.
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Bdfoie 4mg capsules may be used to titrate the total dose as per physician guidance.
Method of Administration:
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Take orally, once daily, at the same time each day.
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Swallow the capsule whole with water—do not crush or chew.
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Can be taken with or without food.
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Avoid taking with grapefruit juice, which may affect absorption.
Precautions:
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Pregnancy warning: Can cause fetal harm; use effective contraception during and after treatment.
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Use with caution in patients with cardiovascular disease, high blood pressure, liver, or kidney problems.
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Regular monitoring of blood pressure, liver and kidney function, and ECG is essential.
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Avoid strenuous physical activity or high-risk tasks if you feel dizzy or fatigued.
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Elderly patients may experience more severe side effects and need closer monitoring.
Drug Interactions:
Lenvatinib may interact with:
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CYP3A4 inhibitors or inducers (e.g., ketoconazole, rifampin)
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Blood pressure medications (may need adjustment)
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Anticoagulants (risk of bleeding)
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Other anti-cancer agents (e.g., everolimus, pembrolizumab)
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QT-prolonging agents (risk of arrhythmia)
Always disclose your full medication list to your doctor.
Allergies:
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Do not take Bdfoie 4mg if allergic to Lenvatinib or any inactive ingredients in the capsule.
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Allergic reactions may include rash, itching, swelling, dizziness, and breathing difficulties.
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Seek emergency help if allergic symptoms occur.
Overdose Information:
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In case of overdose, seek immediate medical attention.
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Symptoms may include severe fatigue, excessive blood pressure rise, or worsening side effects.
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There is no specific antidote; treatment is supportive.
Missed Dose Instructions:
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If a dose is missed and less than 12 hours have passed, take the dose as soon as remembered.
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If more than 12 hours have passed, skip the missed dose and resume your regular schedule.
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Do not double the dose to compensate for a missed one.
Additional Notes:
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Blood pressure should be checked regularly, especially during the first weeks of treatment.
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Patients may require dose adjustments or temporary interruption of treatment for side effect management.
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Caregivers should wear gloves when handling the capsules, especially if they are broken.
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This medication is often part of combination regimens with immunotherapy in modern cancer protocols.
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Keep a written or digital record of your daily dose, side effects, and lab reports to share with your oncologist.
