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Intaxel 100mg - Paclitaxel Injections

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Intaxel 100mg - Paclitaxel Injections

Intaxel 100mg is a plant-derived chemotherapy injection used to treat a variety of cancers including breast, ovarian, and lung cancer. It works by preventing the growth and spread of cancer cells by disrupting their cell division process.

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Description Product Details
General Information:
Generic Name: Paclitaxel
Brand Name: Intaxel 100mg
Packing: Single-use glass vial
Strength: 100 mg/16.7 mL (6 mg/mL)
Manufacturer: Fresenius Kabi
Form: Concentrated solution for infusion
Category: Antineoplastic Agent – Taxane derivative
Product Introduction:
Intaxel 100mg contains Paclitaxel, a cytotoxic agent from the taxane class, extracted from the bark of the Pacific yew tree. It is widely used in oncology for solid tumors, either alone or in combination with other agents. This medication is administered as an intravenous infusion in a hospital or clinical setting under specialist supervision.
Uses:
Intaxel 100mg is used in the treatment of:
  1. Metastatic breast cancer
  2. Advanced ovarian cancer
  3. Non-small cell lung cancer (NSCLC)
  4. Pancreatic cancer (in combination with gemcitabine)
  5. AIDS-related Kaposi’s sarcoma
  6. Head and neck cancers (off-label use)
Storage Instructions:
  1. Store at 15°C to 30°C (room temperature)
  2. Do not refrigerate or freeze
  3. Protect from light and moisture
  4. Once diluted, the infusion should be used as per hospital/pharmacy protocol
  5. Keep out of reach of children
How It Works (Mechanism of Action):
Paclitaxel stabilizes microtubules and prevents their depolymerization, which interferes with normal breakdown of microtubules during cell division. This results in mitotic arrest and eventual cell death of cancer cells.
Side Effects:
Common side effects:
  1. Nausea and vomiting
  2. Hair loss (alopecia)
  3. Fatigue
  4. Diarrhea or constipation
  5. Tingling or numbness (neuropathy)
  6. Low white blood cell count (neutropenia)
Severe side effects:
  1. Allergic reactions (difficulty breathing, rash, low blood pressure)
  2. Infections due to bone marrow suppression
  3. Heart problems like bradycardia
  4. Liver enzyme elevation
  5. Severe neuropathy
Dosage (Typical Recommended Dose):
  1. Dosage is based on body surface area (BSA)
  2. Common regimens include:
    1. 175 mg/m² every 3 weeks (as a 3-hour infusion)
    2. 80–100 mg/m² weekly for certain cancers
  3. 100 mg vials are typically used to achieve the required dose depending on patient-specific needs
Method of Administration:
  1. Administered by IV infusion over 3 hours
  2. Pre-medication with corticosteroids, antihistamines, and H2 blockers is required to prevent hypersensitivity reactions
  3. Must be diluted in 5% Dextrose or Normal Saline
  4. Given only in clinical settings under medical supervision
Precautions:
  1. Ensure normal blood counts and liver function before each cycle
  2. Not safe for pregnant or breastfeeding women
  3. Use effective contraception during and after treatment
  4. Monitor for signs of neuropathy, infection, or allergic reactions
  5. Avoid exposure to sick individuals due to lowered immunity
Drug Interactions:
  1. Enhanced side effects when used with cisplatin, doxorubicin, or carboplatin
  2. Affects and is affected by drugs that induce or inhibit CYP3A4/CYP2C8 enzymes
  3. Avoid live vaccines
  4. Always inform your doctor of any supplements or herbal medicines being used
Allergies:
  1. Contraindicated in patients allergic to Paclitaxel or the solvent Cremophor EL
  2. Allergic reactions may include rash, itching, swelling, or difficulty breathing
  3. Emergency treatment may be required for anaphylaxis
Overdose Information:
  1. Overdose symptoms: Severe bone marrow suppression, mucositis, neuropathy
  2. No specific antidote available
  3. Management is supportive with intensive monitoring
Missed Dose Instructions: 
  1. Contact your oncologist immediately if a dose is missed
  2. Do not reschedule without professional advice
  3. A new treatment plan will be developed by your doctor based on response and lab values
Additional Notes:  
  1. Temporary hair loss is expected but regrowth occurs after treatment
  2. Patients may experience neuropathy even after stopping treatment—report any changes early
  3. Routine blood tests before each dose are essential
  4. Avoid alcohol and cold exposure during and after treatment
  5. Hydration and proper nutrition can support recovery and reduce side effects

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