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Invista (50mg / 70mg / 100mg) - Dasatinib Tablets

Invista (50mg / 70mg / 100mg) - Dasatinib Tablets

Invista contains Dasatinib, a targeted therapy used to treat certain types of leukemia, including CML and ALL. It is a second-generation BCR-ABL tyrosine kinase inhibitor that helps stop the growth of cancer cells.

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Description Product Details
General Information:
Generic Name: Dasatinib
Brand Name: Invista
Packing: 10 Tablets
Strengths: 50mg, 70mg, 100mg
Manufacturer: Dr Reddy'S Laboratories Ltd
Form: Film-coated Tablets
Category: Antineoplastic, Tyrosine Kinase Inhibitor
Route of Administration: Oral
Prescription Status: Rx-only
Product Introduction:
Invista is an oral chemotherapy medication used for the treatment of Philadelphia chromosome-positive leukemias. It is effective in cases resistant to imatinib and is typically used in both adult and pediatric patients under oncologist supervision.
Uses:
Invista (Dasatinib) is used for the treatment of:
  1. Chronic Myeloid Leukemia (CML) – all phases
  2. Philadelphia chromosome-positive Acute Lymphoblastic Leukemia (Ph+ ALL)
  3. CML resistant or intolerant to prior therapy including imatinib
  4. First-line treatment in newly diagnosed Ph+ CML
  5. Maintenance therapy post-stem cell transplantation in leukemia
  6. Off-label uses in other BCR-ABL or SRC-family kinase-driven cancers
Storage Instructions:
  1. Store below 30°C in a dry place
  2. Protect from light and moisture
  3. Keep out of reach of children and pets
  4. Do not use past expiry date
How It Works (Mechanism of Action):
Dasatinib is a tyrosine kinase inhibitor that blocks the BCR-ABL fusion protein, a key driver of leukemic cell proliferation in Ph+ leukemias. It also inhibits SRC family kinases, c-KIT, EPHA2, and PDGFR-β, contributing to its broad anti-leukemic activity.
Side Effects:
Common side effects:
  1. Headache
  2. Nausea
  3. Diarrhea
  4. Fatigue
  5. Fluid retention
  6. Skin rash
  7. Myelosuppression (low blood counts)
Severe side effects:
  1. Pleural effusion (fluid in lungs)
  2. Pulmonary arterial hypertension (PAH)
  3. QT prolongation
  4. Severe bleeding or hemorrhage
  5. Pancreatitis or liver dysfunction
Dosage (Typical Recommended Dose):
  1. For CML (chronic phase): 100 mg orally once daily
  2. For CML (accelerated or blast phase), or Ph+ ALL: 140 mg once daily (in divided doses if necessary)
  3. Dosing may be adjusted based on response and tolerability
  4. Pediatric dosing varies by body surface area and age
Method of Administration:
  1. Administer orally, once daily
  2. Can be taken with or without food
  3. Swallow tablet whole with water; do not crush or split
  4. Avoid grapefruit or grapefruit juice, which may alter drug absorption
Precautions:
  1. Caution in patients with cardiac history, fluid retention, or liver impairment
  2. Regular monitoring of blood counts, ECG, liver function, and pulmonary symptoms
  3. Risk of bleeding and myelosuppression – dose adjustment may be needed
  4. Use effective contraception during treatment and for some time after
  5. Avoid in pregnancy unless absolutely necessary – may cause fetal harm
Drug Interactions:
  1. Avoid CYP3A4 inhibitors (e.g., ketoconazole, ritonavir) – may increase toxicity
  2. Avoid CYP3A4 inducers (e.g., rifampin, phenytoin) – may reduce efficacy
  3. May interact with antacids and proton pump inhibitors – separate administration by several hours
  4. Can increase serum levels of other CYP3A4 substrates
Allergies:
  1. Contraindicated in individuals with known hypersensitivity to Dasatinib
  2. Watch for allergic symptoms: swelling, difficulty breathing, rash, severe itching
Overdose Information:
  1. Symptoms may include severe myelosuppression, diarrhea, or liver issues
  2. In case of overdose, seek emergency medical attention
  3. Supportive care and monitoring are essential – no specific antidote available
Missed Dose Instructions:
  1. Take the missed dose as soon as you remember on the same day
  2. Skip the missed dose if it is almost time for the next dose
  3. Do not double up to make up for a missed dose
Additional Notes:
  1. Patients must be monitored regularly for hematologic response and side effects
  2. May cause growth delays in children—monitor pediatric growth parameters
  3. Pulmonary and cardiovascular evaluation is necessary during prolonged therapy
  4. Dispose of unused medicine as per hazardous drug handling protocols

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