0
₹0 0
Nextgen Biotech

Call us:

menu

Endace (40mg / 160mg) - Megestrol Acetate Tablets

Endace (40mg / 160mg) - Megestrol Acetate Tablets

Endace contains Megestrol Acetate, a synthetic progestin used primarily to treat appetite loss, weight loss in cancer or AIDS patients, and hormone-responsive cancers such as breast and endometrial cancer. It helps stimulate appetite and slow the growth of certain tumors.

Select the packing Size:

Choose Quantity:

-
+
+ Add To Cart
Add to wishlist
Share
Description Product Details
General Information:
Generic Name: Megestrol Acetate
Brand Name: Endace
Packing: 10 tabs in strips
Strength: 40 mg and 160 mg tablets
Manufacturer: Samarth Life Sciences Pvt Ltd
Form: Oral tablet
Category: Hormonal therapy, Antineoplastic, Progestin
Product Intro:
Endace is an oral hormone therapy that provides both palliative and supportive care benefits. It is particularly useful in managing cachexia (wasting syndrome) and can enhance the quality of life in patients with chronic illnesses or undergoing cancer treatment.
Uses (Indications):
  1. Appetite stimulation and weight gain in patients with cancer or AIDS
  2. Palliative treatment of advanced breast cancer
  3. Treatment of endometrial carcinoma
  4. Management of anorexia-cachexia syndrome
  5. Occasionally used in off-label settings for hot flashes in menopausal women
  6. Supportive therapy for malnutrition-related weight loss
Storage Instructions:
  1. Store at room temperature between 20°C to 25°C
  2. Protect from heat, moisture, and direct light
  3. Keep out of reach of children and pets
  4. Do not use if tablets are discolored or broken
How It Works (Mechanism of Action):
Megestrol Acetate acts as a synthetic progestin, binding to progesterone receptors. It exerts anti-estrogenic effects, which help slow down the growth of hormone-sensitive tumors. Additionally, it enhances appetite by acting on the hypothalamic feeding centers and possibly increasing neuropeptide Y activity.
Side Effects:
Common Side Effects:
  1. Weight gain
  2. Increased appetite
  3. Mild fluid retention
  4. Nausea
  5. Fatigue
  6. Menstrual irregularities
Serious Side Effects:
  1. Deep vein thrombosis (DVT) or blood clots
  2. Pulmonary embolism
  3. Adrenal suppression (especially with long-term use)
  4. Hyperglycemia (especially in diabetic patients)
  5. Cushingoid appearance with prolonged use
  6. Allergic reactions (rare but serious)
Dosage (Typical Recommended Dose):
  1. For appetite stimulation: 400–800 mg per day in divided doses or once daily (usually 160 mg tablet once or twice daily)
  2. For breast cancer: 160 mg/day or higher based on clinical response
  3. For endometrial carcinoma: 40–160 mg/day depending on treatment goals
  4. Dose may vary depending on patient condition and physician guidance
  5. Dosage tapering may be necessary when discontinuing after long-term use
Method of Administration:
  1. Take orally with or without food
  2. Swallow the tablet whole with water
  3. Take at the same time each day for consistency
  4. If GI discomfort occurs, take with food or milk
Precautions:
  1. Use with caution in patients with a history of blood clots or thromboembolic disorders
  2. Monitor blood sugar levels in diabetic patients
  3. Not recommended for use in pregnancy or lactation
  4. Avoid abrupt discontinuation after long-term use to prevent adrenal insufficiency
  5. May cause fluid retention — monitor in patients with cardiac or renal conditions
  6. Periodic evaluation of adrenal and liver function may be required
Drug Interactions:
  1. May alter the effectiveness of insulin or oral antidiabetic drugs
  2. Corticosteroids – may increase risk of adrenal suppression
  3. CYP3A4 inducers (e.g., rifampin) – may reduce drug levels
  4. Warfarin – increased risk of bleeding (monitor INR closely)
  5. Estrogen-containing medications – may oppose therapeutic effect
Allergies (Warnings for Allergic Reactions):
  1. Patients allergic to Megestrol Acetate or other progestins should avoid use
  2. Watch for signs like rash, itching, swelling, difficulty breathing
  3. Discontinue and seek immediate medical attention if allergic reaction occurs
Overdose Information:
  1. Symptoms may include nausea, vomiting, shortness of breath, or severe swelling
  2. No specific antidote; treatment is symptomatic and supportive
  3. Seek emergency medical attention immediately in case of suspected overdose
  4. Long-term overdose can cause adrenal suppression or blood clot risks
Missed Dose Instructions:
  1. Take the missed dose as soon as you remember
  2. If it’s close to the next dose, skip the missed dose — do not double the dose
  3. Resume your regular dosing schedule thereafter
Additional Notes:
  1. Weight and appetite should be monitored periodically
  2. May take 2–3 weeks for full effects to be observed
  3. Long-term use should be supervised with hormone level and adrenal function tests
  4. Inform your doctor of any leg pain, chest pain, or breathing difficulty
  5. Inform all healthcare providers you're taking this medicine, especially before surgery

In The Same Category

Cart