Ibrunat 140mg is an oral targeted therapy used to treat various blood cancers such as CLL, SLL, and MCL. It works by blocking Bruton's tyrosine kinase (BTK), a protein essential for cancer cell survival.
Ibrunat 140mg, manufactured by Natco Pharma, contains Ibrutinib, a Bruton's Tyrosine Kinase (BTK) inhibitor. This capsule is prescribed for treating B-cell malignancies such as mantle cell lymphoma (MCL), chronic lymphocytic leukemia (CLL), and Waldenström's macroglobulinemia (WM). It is a first-in-class targeted therapy that significantly slows cancer progression and improves survival.
Uses:
Chronic Lymphocytic Leukemia (CLL)
Small Lymphocytic Lymphoma (SLL)
Mantle Cell Lymphoma (MCL)
Waldenström's Macroglobulinemia (WM)
Marginal Zone Lymphoma (MZL)
Chronic Graft versus Host Disease (cGVHD) in select cases
Storage Instructions:
Store at 20°C–25°C (68°F–77°F)
Protect from light and moisture
Keep in original container
Keep out of reach of children
How it Works (Mechanism of Action):
Ibrutinib selectively and irreversibly binds to Bruton's tyrosine kinase (BTK), an enzyme vital for B-cell receptor signaling.
Inhibition of BTK prevents survival and proliferation of malignant B-cells
Disrupts signaling needed for cancer cell migration and adhesion
Leads to cancer cell apoptosis (programmed cell death) and slows disease progression
Side Effects:
Common Side Effects:
Diarrhea
Fatigue
Nausea
Muscle pain
Bruising or bleeding
Upper respiratory tract infections
Serious Side Effects:
Atrial fibrillation or heart rhythm problems
Hypertension (high blood pressure)
Bleeding events (serious or fatal)
Infections (bacterial, viral, fungal)
Tumor lysis syndrome
Secondary cancers (rare)
Dosage (Typical Recommended Dose):
MCL: 560 mg once daily (usually 4 capsules of 140 mg)
CLL, SLL, WM: 420 mg once daily (3 capsules of 140 mg)
Doses may be modified based on tolerance and side effects
Take daily until disease progression or unacceptable toxicity
Method of Administration:
Take the capsule orally once daily with a full glass of water
Do not open, crush, or chew the capsules
Can be taken with or without food
Take at the same time every day for best results
Precautions:
Monitor for bleeding, heart rhythm changes, and infection
Not recommended during pregnancy or breastfeeding
Use effective contraception during and at least 1 month after treatment
Regular blood tests and ECGs may be required
Caution in patients with cardiac disorders or hypertension
