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Relipoietin 4000iu - Erythropoietin Injection

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Relipoietin 4000iu - Erythropoietin Injection

Relipoietin 4000 IU is a recombinant human erythropoietin alfa injection used to treat anemia caused by chronic kidney disease, chemotherapy, or other medical conditions. It stimulates bone marrow to increase red blood cell production and reduce the need for blood transfusions.

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Description Product Details
General Information:
Generic Name: Erythropoietin Alfa
Brand Name: Relipoietin
Packing: Single-use vial or prefilled syringe
Strength: 4000 IU per 1 ml
Manufacturer: Reliance Life Sciences
Form: Injection (solution for injection)
Category: Hematopoietic Agent / Anti-anemic Agent
Product Intro:
Relipoietin 4000 IU is a synthetic erythropoietin formulation that mimics the natural hormone produced by the kidneys. It is manufactured by Reliance Life Sciences and is widely used in the treatment of anemia associated with chronic diseases. It helps in improving oxygen levels, energy, and overall quality of life for patients suffering from anemia.
Uses:
  1. Anemia in Chronic Kidney Disease (CKD) – in dialysis and non-dialysis patients
  2. Chemotherapy-induced Anemia – in cancer patients undergoing treatment
  3. Anemia in HIV-infected patients – particularly those treated with zidovudine
  4. Bone marrow failure syndromes – like myelodysplastic syndromes
  5. Anemia in preterm infants – under strict medical supervision
  6. To reduce the need for blood transfusions in surgical or critically ill patients
Storage Instructions:
  1. Store between 2°C and 8°C in a refrigerator
  2. Do not freeze
  3. Protect from light and heat
  4. Do not shake the vial or syringe
  5. Allow the medication to come to room temperature before injection
How it Works (Mechanism of Action):
Erythropoietin alfa stimulates erythroid progenitor cells in the bone marrow, promoting the development of red blood cells. By mimicking the natural erythropoietin hormone, it increases hemoglobin levels and enhances oxygen-carrying capacity in the blood.
Side Effects:
Common Side Effects:
  1. Pain or redness at the injection site
  2. Headache
  3. Fever
  4. Muscle pain
  5. Nausea
Severe Side Effects:
  1. High blood pressure (hypertension)
  2. Thrombosis (blood clots)
  3. Seizures
  4. Pure Red Cell Aplasia (PRCA) – a rare but serious immune-mediated condition
  5. Severe allergic reactions including rash, swelling, or anaphylaxis
Dosage (Typical Recommended Dose):
  1. CKD (dialysis patients): 50–100 IU/kg IV or SC, three times per week
  2. CKD (non-dialysis): 75–150 IU/kg SC per week
  3. Cancer-related anemia: 150 IU/kg SC thrice weekly or 40,000 IU once weekly
  4. Dose adjustment based on hemoglobin response and clinical condition
Method of Administration:
  1. Administered either subcutaneously (SC) or intravenously (IV)
  2. Administered by a healthcare professional or trained caregiver
  3. Rotate injection sites for subcutaneous use
  4. Do not use the injection if the solution appears discolored or contains particles
Precautions:
  1. Monitor hemoglobin levels regularly
  2. Avoid rapid increases in hemoglobin
  3. Monitor blood pressure and treat if elevated
  4. Use with caution in patients with heart disease, stroke history, or seizure disorders
  5. Ensure adequate iron stores, as iron deficiency can reduce efficacy
Drug Interactions:
  1. Iron supplements – often co-administered to enhance erythropoiesis
  2. Antihypertensive drugs – monitor BP closely
  3. Immunosuppressants – monitor bone marrow function
  4. No major drug-drug interactions, but monitor in polypharmacy patients
Allergies:
  1. Contraindicated in patients with known hypersensitivity to erythropoietin or excipients
  2. Watch for signs of an allergic reaction:
    1. Skin rash or hives
    2. Difficulty breathing
    3. Swelling of face, lips, or throat
Overdose Information:
  1. Symptoms: Excessive hemoglobin rise, risk of blood clots or high blood pressure
  2. Action: Discontinue medication and monitor symptoms
  3. In severe cases, therapeutic phlebotomy may be required
Missed Dose Instructions:
  1. Take the missed dose as soon as remembered
  2. If it is near the time for the next dose, skip the missed dose
  3. Do not double the dose to make up for a missed one
Additional Notes:
  1. Treatment response may take a few weeks
  2. Patients may need iron, folate, and vitamin B12 supplementation
  3. Inform your doctor if you feel fatigued, dizzy, or short of breath
  4. Avoid smoking and manage chronic illnesses for better response

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