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Daslemia (70mg / 100mg) - Dasatnib Tablets

Daslemia (70mg / 100mg) - Dasatnib Tablets

Daslemia contains Dasatinib, an oral tyrosine kinase inhibitor used to treat chronic myeloid leukemia (CML) and Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL). It works by blocking abnormal proteins that promote cancer cell growth and survival.

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Description Product Details
General Information:
Generic Name: Dasatinib
Brand Name: Daslemia
Packing: Bottle pack of 30 and 60 tablets
Strength: 70 mg and 100 mg
Manufacturer: Intas Pharmaceuticals Ltd
Form: Oral tablets
Category: Antineoplastic, Tyrosine Kinase Inhibitor (TKI)
Product Intro:
Daslemia is a targeted anticancer therapy formulated for oral use. It is used to manage leukemia by specifically inhibiting kinases responsible for cancer cell multiplication, especially in cases resistant or intolerant to first-line treatments like imatinib.
Uses (Indications):
  1. Chronic Myeloid Leukemia (CML) – in chronic, accelerated, and blast phases
  2. Philadelphia chromosome-positive Acute Lymphoblastic Leukemia (Ph+ ALL)
  3. Pediatric CML (where approved)
  4. CML cases resistant or intolerant to other TKIs (e.g., imatinib)
  5. Maintenance therapy after stem cell transplant (as advised by oncologist)
  6. Investigational use in other cancers involving abnormal tyrosine kinase activity
Storage Instructions:
  1. Store at 20°C to 25°C (room temperature)
  2. Keep away from moisture and direct sunlight
  3. Store in the original container until use
  4. Keep out of reach of children and pets
How It Works (Mechanism of Action):
Dasatinib blocks several tyrosine kinases such as BCR-ABL, SRC family kinases, c-KIT, and PDGFR. In CML and Ph+ ALL, the BCR-ABL fusion gene causes uncontrolled cell division. Daslemia targets and inhibits these proteins, leading to reduced cancer cell growth and induced apoptosis (cell death).
Side Effects:
Common Side Effects:
  1. Nausea
  2. Headache
  3. Diarrhea
  4. Fatigue
  5. Rash
  6. Muscle and joint pain
Serious Side Effects:
  1. Myelosuppression – low white cells, red cells, or platelets
  2. Pleural or pericardial effusion (fluid buildup around lungs/heart)
  3. QT prolongation – risk of abnormal heart rhythms
  4. Pulmonary arterial hypertension (PAH)
  5. Liver enzyme elevation
  6. Severe bleeding events (especially GI or intracranial)
Dosage (Typical Recommended Dose):
  1. Chronic Phase CML (Adults): 100 mg once daily
  2. Accelerated or Blast Phase CML and Ph+ ALL: 140 mg once daily
  3. Dosing may vary based on patient weight, age, tolerability, and response
  4. Pediatric dosing is weight-based and decided by the oncologist
Method of Administration:
  1. Take orally with or without food
  2. Swallow whole with water (do not break, crush, or chew)
  3. Take at the same time each day for consistency
  4. If vomiting occurs after dose, do not retake without consulting a doctor
Precautions:
  1. Frequent monitoring of complete blood counts is required
  2. Monitor for fluid retention signs like chest pain or shortness of breath
  3. Use with caution in patients with heart problems or history of arrhythmia
  4. Not safe during pregnancy – use effective contraception
  5. Avoid breastfeeding while on therapy
  6. Monitor liver function and electrolytes during treatment
Drug Interactions:
  1. CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin) – may increase drug levels
  2. CYP3A4 inducers (e.g., rifampin, phenytoin) – may reduce drug effectiveness
  3. Antacids, proton pump inhibitors – may interfere with absorption
  4. QT-prolonging drugs – increased risk of heart rhythm disturbances
  5. Herbal supplements like St. John's Wort – to be avoided
Allergies (Warnings for Allergic Reactions):
  1. Hypersensitivity reactions can occur but are rare
  2. Symptoms may include rash, itching, swelling, dizziness, or trouble breathing
  3. Stop medication and seek immediate medical attention if any allergic reaction is suspected
Overdose Information:
  1. Symptoms may include extreme weakness, severe nausea, vomiting, low blood counts, or irregular heartbeat
  2. No specific antidote is available
  3. Supportive care in a hospital setting is required, including cardiac and blood count monitoring
Missed Dose Instructions:
  1. If a dose is missed, take it as soon as remembered unless it is close to the next scheduled dose
  2. Do not take a double dose to make up for the missed one
  3. If multiple doses are missed, inform your healthcare provider
Additional Notes:
  1. Avoid grapefruit and grapefruit juice – it may increase dasatinib levels in the body
  2. Maintain hydration unless advised otherwise
  3. Adherence is critical – do not stop or alter the dose without medical advice
  4. Notify your doctor immediately if experiencing symptoms like bleeding, persistent fever, or chest pain
  5. Periodic ECG may be required for patients at risk of cardiac complications

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