Product Introduction:
Oxa 50mg contains Oxaliplatin, a third-generation platinum compound. It is used in combination with other chemotherapy drugs to treat advanced or metastatic colorectal cancer. The medication is administered intravenously under the supervision of a qualified oncologist.
Uses:
Oxa 50mg is used in the treatment of:
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Advanced colorectal cancer
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Adjuvant treatment of stage III colon cancer after surgical resection
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As part of the FOLFOX regimen (with 5-FU and Leucovorin)
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Gastrointestinal cancers (in specific regimens)
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Gastric or pancreatic cancers (off-label use in select cases)
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Combination chemotherapy protocols in metastatic cases
Storage Instructions:
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Store at 2°C to 8°C (refrigerator)
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Do not freeze
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Protect from light
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After dilution, use within the period recommended by the manufacturer or hospital policy
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Keep out of reach of children
How It Works (Mechanism of Action):
Oxaliplatin forms platinum-DNA adducts, which cause inhibition of DNA replication and transcription. This leads to irreversible DNA damage, impairing cancer cell division and resulting in cell death. It is especially effective when used with fluoropyrimidines like 5-Fluorouracil.
Side Effects:
Common side effects include:
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Nausea and vomiting
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Diarrhea or constipation
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Peripheral neuropathy (tingling, numbness)
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Fatigue
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Loss of appetite
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Low blood counts (anemia, leukopenia, thrombocytopenia)
Severe side effects may include:
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Allergic reactions (anaphylaxis)
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Severe peripheral neuropathy
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Pulmonary toxicity
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Hepatotoxicity
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Hearing loss (rare)
Dosage (Typical Recommended Dose):
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The standard dosage is 85 mg/m² of body surface area every 2 weeks
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Oxa 50mg vials are used as part of the total calculated dose
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Dose adjustments may be required based on toxicity or organ function
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Always administered in combination with other chemotherapeutic agents unless otherwise directed
Method of Administration:
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Administered as an intravenous infusion over 2 hours
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Must be diluted in 5% Dextrose (not saline)
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Administered by a trained oncology team
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Anti-nausea medications are usually given before infusion
Precautions:
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Avoid cold drinks, cold environments, and touching cold objects post-treatment to reduce neuropathy risk
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Regular monitoring of blood counts, liver, and kidney function is necessary
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Use with caution in patients with pre-existing neuropathy or renal impairment
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Not safe during pregnancy or breastfeeding
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Use effective contraception during and after treatment
Drug Interactions:
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Other neurotoxic drugs (e.g., paclitaxel, cisplatin) can worsen nerve damage
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May interact with live vaccines (increased risk of infection)
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Caution with drugs affecting bone marrow or kidneys
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Inform your healthcare provider about all other medications being taken
Allergies:
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Do not use if allergic to Oxaliplatin or other platinum-containing compounds
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Allergic reactions may include rash, wheezing, facial swelling, or low blood pressure – immediate medical attention is required
Overdose Information:
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Overdose may lead to severe neurotoxicity, bone marrow suppression, and organ damage
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No specific antidote; treatment is supportive and symptomatic
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Emergency care should be sought immediately
Missed Dose Instructions:
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If a dose is missed, consult your oncologist as soon as possible
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Do not adjust or reschedule chemotherapy without professional guidance
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Follow the prescribed cycle and schedule strictly
Additional Notes:
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Patients should be educated about neuropathy triggers (e.g., cold)
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Hydration before and after treatment may reduce toxicity
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Report unusual bleeding, bruising, fever, or infections to your doctor immediately
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Treatment may last for several months depending on the condition and response
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Periodic assessment of treatment efficacy and side effects is essential
