Product Introduction:
Luprodex 11.25mg contains Leuprolide Acetate, a synthetic analog of Gonadotropin-Releasing Hormone (GnRH). It is designed for extended-release over 12 weeks, offering convenience and efficacy in the management of hormone-dependent conditions. It is administered as a depot intramuscular injection by a healthcare provider.
Uses:
Luprodex 11.25mg is indicated for the treatment of:
-
Advanced Prostate Cancer – testosterone suppression
-
Endometriosis – controls estrogen-driven symptoms
-
Uterine Fibroids – reduces fibroid size and symptoms
-
Central Precocious Puberty (CPP) – delays early puberty in children
-
Breast Cancer – in premenopausal women with hormone-positive tumors (off-label)
-
Assisted Reproductive Technology (ART) – used in IVF cycles for hormonal regulation
Storage Instructions:
-
Store below 25°C (77°F)
-
Protect from direct sunlight and moisture
-
Do not freeze
-
Use immediately after reconstitution
-
Keep out of reach of children
How It Works (Mechanism of Action):
Leuprolide Acetate initially stimulates the release of LH and FSH, causing a short-term rise in testosterone or estrogen levels (flare effect). With continuous use, it downregulates GnRH receptors, reducing LH and FSH secretion, which leads to a reduction in sex hormone levels, halting the progression of hormone-sensitive diseases.
Side Effects:
Common side effects:
-
Hot flashes
-
Sweating
-
Headache
-
Fatigue
-
Mood changes
-
Injection site pain
-
Decreased libido
Serious side effects:
-
Osteoporosis or bone thinning
-
Depression or emotional changes
-
Blood sugar elevation or new-onset diabetes
-
Irregular heart rhythm (QT prolongation)
-
Tumor flare during initial treatment phase
-
Severe allergic reactions (e.g., anaphylaxis, angioedema)
Dosage (Typical Recommended Dose):
-
One 11.25 mg injection administered once every 3 months (12 weeks)
-
Dosage frequency and duration depend on the disease being treated
-
To be administered by a qualified medical professional
Method of Administration:
-
Given via deep intramuscular injection (usually gluteal muscle)
-
Requires reconstitution with provided sterile diluent prior to administration
-
Only to be given under medical supervision
-
Injection sites should be rotated for repeated doses
Precautions:
-
Contraindicated in pregnancy and lactation
-
Use non-hormonal contraception during treatment
-
Monitor for bone density loss, especially in long-term therapy
-
Be cautious in patients with heart conditions, psychiatric history, or diabetes
-
May worsen symptoms initially due to hormonal surge (tumor flare)
Drug Interactions:
Luprodex 11.25mg may interact with:
-
Medications that prolong QT interval (e.g., amiodarone, fluoroquinolones)
-
Diabetes medications (can affect blood sugar levels)
-
Corticosteroids (may exacerbate bone loss)
-
Other hormone therapies
Always inform your doctor about all medications and supplements you are using.
Allergies:
-
Do not use if allergic to Leuprolide, GnRH agonists, or any component of the injection
-
Signs of an allergic reaction may include rash, itching, swelling, dizziness, or difficulty breathing
Overdose Information:
-
Overdose is rare and usually due to misadministration
-
Symptoms may include excess hormonal suppression, mood changes, or fatigue
-
No specific antidote; supportive treatment is recommended
-
Seek immediate medical help if overdose is suspected
Missed Dose Instructions:
-
Contact your doctor immediately if a dose is missed
-
Timely dosing is crucial for effective hormone suppression
-
Do not self-administer or adjust the schedule without medical advice
Additional Notes:
-
Bone health should be monitored with DEXA scans during long-term therapy
-
Consider calcium and vitamin D supplementation
-
Regular PSA (for prostate cancer) or hormonal level tests are advised
-
Patients may carry a medical alert card indicating treatment with Luprodex
-
Inform the healthcare provider of any planned surgeries or major procedures
