Product Introduction:
Lenvat 10mg is a targeted therapy designed for the treatment of multiple advanced-stage cancers. It is particularly effective in cases where other traditional treatments like chemotherapy or radiation have failed or are unsuitable. As a multi-kinase inhibitor, it provides a modern and more precise approach to slowing cancer progression.
Uses:
Lenvat 10mg is used in the treatment of:
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Differentiated Thyroid Cancer (DTC) – especially when not responding to radioactive iodine therapy
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Hepatocellular Carcinoma (HCC) – as first-line therapy for unresectable liver cancer
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Renal Cell Carcinoma (RCC) – often used in combination with other agents like pembrolizumab
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Endometrial Cancer – typically used with immunotherapy agents
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Medullary Thyroid Cancer – in select cases under physician supervision
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Other advanced or metastatic solid tumors – as part of clinical protocol or off-label usage
Storage Instructions:
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Store at room temperature (20°C to 25°C).
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Keep away from light, heat, and moisture.
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Do not remove the capsules from their blister pack until use.
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Keep out of reach of children and pets.
How It Works (Mechanism of Action):
Lenvatinib is a multi-targeted tyrosine kinase inhibitor. It blocks several receptors like VEGFR, FGFR, PDGFR, RET, and KIT, which are involved in cancer cell proliferation and angiogenesis. By inhibiting these pathways, Lenvatinib slows tumor growth and disrupts the blood supply that supports cancer cell survival.
Side Effects:
Common side effects:
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High blood pressure
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Diarrhea
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Fatigue or weakness
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Decreased appetite
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Weight loss
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Joint or muscle pain
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Nausea and vomiting
Severe side effects:
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Liver and kidney dysfunction
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Heart complications (e.g., heart failure, arrhythmias)
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Gastrointestinal perforation or bleeding
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Blood clots (e.g., DVT, pulmonary embolism)
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Proteinuria (excess protein in urine)
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Rare cases of Posterior Reversible Encephalopathy Syndrome (PRES)
Dosage (Typical Recommended Dose):
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The typical starting dose is dependent on cancer type and patient’s body weight.
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For HCC: 8 mg daily (if <60 kg) or 12 mg daily (if ≥60 kg)
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For Thyroid/RCC: up to 24 mg/day (can be titrated using 4mg, 10mg, or 18mg capsules)
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Lenvat 10mg is used in combinations to build up the required daily dose.
Method of Administration:
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Take the capsule orally, once daily.
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Swallow whole with water—do not crush or chew.
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Take with or without food.
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Try to take it at the same time every day for consistency.
Precautions:
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Not recommended during pregnancy or breastfeeding due to risk to the fetus or infant.
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Use effective contraception during treatment and for at least 1 month after stopping.
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Monitor blood pressure and organ functions regularly.
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Exercise caution in patients with liver, kidney, or cardiovascular disease.
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Avoid operating heavy machinery if feeling dizzy or fatigued.
Drug Interactions:
Lenvat 10mg may interact with:
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CYP3A4 inhibitors/inducers (e.g., ketoconazole, carbamazepine)
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Antihypertensive drugs
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Anticoagulants and antiplatelets (risk of bleeding)
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QT-prolonging drugs
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Other anti-cancer medications or immunotherapies
Always inform your physician of all medications and supplements you are taking.
Allergies:
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Avoid use if allergic to Lenvatinib or any inactive components.
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Signs of allergic reactions include rash, itching, swelling, dizziness, or breathing difficulty.
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Seek immediate medical help in case of allergic response.
Overdose Information:
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In case of an overdose, seek emergency medical attention.
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Symptoms may include excessive fatigue, uncontrolled blood pressure, or severe side effects.
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No specific antidote exists; treatment is supportive.
Missed Dose Instructions:
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If missed, and less than 12 hours have passed, take it as soon as possible.
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If more than 12 hours have passed, skip the missed dose and continue the next scheduled dose.
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Do not take a double dose to make up for the missed one.
Additional Notes:
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Blood pressure monitoring is vital, especially during the first two weeks of treatment.
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Patients should be advised about the potential for impaired wound healing.
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Do not share this medication with others.
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Always follow the doctor's instructions carefully and attend scheduled follow-ups and lab tests.
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Inform your healthcare provider about any surgery plans before starting or while taking Lenvatinib.
