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Gros 260mg - Paclitaxel Injections

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Gros 260mg - Paclitaxel Injections

Gros 260mg is a chemotherapeutic injection used in the treatment of various cancers including breast, ovarian, lung, and pancreatic cancers. It works by inhibiting the growth and spread of cancer cells in the body through a unique mechanism of action.

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Description Product Details
General Information:
Generic Name: Paclitaxel
Brand Name: Gros 260mg
Packing: Single-use vial
Strength: 260 mg/43.4 mL (6 mg/mL)
Manufacturer: [Insert Manufacturer Name]
Form: Injectable concentrate
Category: Antineoplastic Agent – Taxane derivative
Product Introduction:
Gros 260mg contains Paclitaxel, a natural, plant-derived anti-cancer agent from the taxane family. It is used alone or in combination with other chemotherapeutic agents and administered by a healthcare professional via intravenous infusion. The drug interferes with cell division, effectively halting tumor growth.
Uses:
Gros 260mg is used for treating:
  1. Metastatic breast cancer
  2. Advanced ovarian cancer
  3. Non-small cell lung cancer (NSCLC)
  4. Pancreatic cancer (in combination with gemcitabine)
  5. Kaposi’s sarcoma in HIV-positive patients
  6. Head and neck cancers (off-label use)
Storage Instructions:
  1. Store at 15°C to 30°C (room temperature)
  2. Do not freeze
  3. Protect from light and moisture
  4. After dilution, use immediately or within the specified time as per clinical guidelines
  5. Keep out of reach of children
How It Works (Mechanism of Action):
Paclitaxel works by stabilizing microtubules, thereby preventing their disassembly during cell division. This interrupts the mitotic process, leading to cell cycle arrest and ultimately cancer cell death. It selectively targets rapidly dividing tumor cells.
Side Effects:
Common side effects:
  1. Hair loss (alopecia)
  2. Nausea and vomiting
  3. Diarrhea or constipation
  4. Peripheral neuropathy (tingling, numbness in hands/feet)
  5. Low white blood cells (neutropenia)
  6. Joint or muscle pain
Severe side effects:
  1. Hypersensitivity or allergic reactions
  2. Severe infections due to myelosuppression
  3. Heart rhythm changes
  4. Liver enzyme elevation
  5. Severe fatigue or anemia
Dosage (Typical Recommended Dose):
  1. 175 mg/m² IV over 3 hours every 3 weeks (standard dose for many indications)
  2. 260mg dosage is commonly used for patients with a larger body surface area
  3. Dosing is personalized based on BSA, clinical condition, and prior treatments
Method of Administration:
  1. Given via intravenous infusion over 3 hours
  2. Requires pre-medication with corticosteroids, antihistamines, and H2 antagonists to prevent hypersensitivity reactions
  3. Must be diluted in a compatible IV solution such as 5% Dextrose or Normal Saline
  4. Administered in a hospital or oncology clinic
Precautions:
  1. Ensure adequate blood counts and liver function before starting therapy
  2. Avoid during pregnancy and lactation – can harm the unborn baby
  3. Use effective contraception during treatment and for a few months after the last dose
  4. Limit exposure to people with infections due to risk of neutropenia
  5. Be cautious of signs of neuropathy or allergic reaction
Drug Interactions:
  1. Increased toxicity when combined with cisplatin or carboplatin
  2. Avoid live vaccines during treatment
  3. May interact with medications metabolized by CYP3A4 and CYP2C8 enzymes
  4. Herbal supplements and over-the-counter medications should be discussed with your doctor
Allergies:
  1. Contraindicated in patients with known allergies to Paclitaxel or its solvent Cremophor EL
  2. Hypersensitivity reactions may include rash, low blood pressure, shortness of breath, or facial swelling
  3. Emergency treatment may be required in case of severe allergic response
Overdose Information:
  1. Symptoms may include severe bone marrow suppression, mucositis, peripheral neuropathy
  2. No specific antidote is known
  3. Treatment is supportive and symptomatic in a clinical setting with close monitoring
Missed Dose Instructions:
  1. Contact your doctor immediately if a dose is missed
  2. Do not self-administer or double the dose
  3. The next dose should be scheduled based on clinical assessment and blood reports
Additional Notes:
  1. Hair loss is reversible post-treatment
  2. Neuropathy may persist after stopping treatment but often improves over time
  3. Routine blood tests before each dose are essential
  4. Avoid alcohol and cold exposure if experiencing neuropathy
  5. Stay hydrated and maintain a balanced diet during chemotherapy

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