Product Introduction:
Endace 40mg is a synthetic progestin with antineoplastic and appetite-stimulating properties. It is commonly used in the palliative treatment of advanced hormone-responsive cancers and cachexia (wasting syndrome) related to cancer or AIDS. The tablets are convenient for daily oral administration and can be used long-term under medical supervision.
Uses:
Endace 40mg is prescribed for:
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Advanced breast cancer (especially hormone receptor-positive)
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Endometrial (uterine) cancer
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Cachexia/anorexia in cancer patients
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AIDS-related wasting syndrome
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Appetite stimulation in elderly or chronically ill patients
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Palliative care to improve quality of life in advanced disease
Storage Instructions:
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Store at room temperature (below 25°C)
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Keep in a cool, dry place, away from direct sunlight
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Keep the medicine in its original packaging
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Keep out of reach of children
How It Works (Mechanism of Action):
Megestrol Acetate is a progestational hormone that works by modulating hormone levels, especially estrogen. It blocks estrogen receptors, reducing the hormonal stimulation of certain cancers. In appetite stimulation, it acts on the hypothalamus, influencing neuropeptide Y pathways and increasing hunger signals, resulting in improved weight gain and nutritional status.
Side Effects:
Common side effects include:
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Weight gain
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Increased appetite
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Mild edema (fluid retention)
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Nausea
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Hot flashes
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Fatigue
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Mood changes
Severe side effects may include:
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Blood clots (deep vein thrombosis, pulmonary embolism)
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Adrenal suppression
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Cushingoid symptoms (moon face, fat redistribution)
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Hyperglycemia (in diabetics)
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Elevated blood pressure
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Rare liver dysfunction
Dosage (Typical Recommended Dose):
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For cancer treatment: 40–320 mg/day in divided or single doses, as prescribed
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For appetite stimulation: Typically starts at 400–800 mg/day in divided doses (higher than cancer treatment)
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Dosage should be individualized by a physician based on indication and patient response
Method of Administration:
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Taken orally with or without food
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Swallow tablets whole with water
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Should be taken at the same time daily for best results
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Follow your doctor's exact dosage instructions
Precautions:
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Not recommended for use in pregnant women – may harm fetus
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Use with caution in diabetics, as it may raise blood sugar
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Monitor for blood clots, especially in patients with a history of thrombosis
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Avoid in patients with active bleeding disorders
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Should not be used as a substitute for primary cancer therapy
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Regular monitoring of weight, blood pressure, and blood glucose is advised
Drug Interactions:
May interact with:
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Warfarin or other anticoagulants – increased bleeding risk
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Diabetes medications – may reduce effectiveness
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Corticosteroids – additive adrenal suppression effects
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Inform your doctor of all medications, herbs, and supplements before starting
Allergies:
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Contraindicated in patients with known hypersensitivity to Megestrol Acetate or any component of the formulation
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Signs of allergic reaction: rash, itching/swelling, severe dizziness, or trouble breathing – seek medical help immediately
Overdose Information:
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Symptoms of overdose may include: extreme weight gain, shortness of breath, swelling, or severe mood changes
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There is no specific antidote; supportive treatment is given
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Contact a medical professional or poison control center in case of suspected overdose
Missed Dose Instructions:
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If a dose is missed, take it as soon as you remember
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If it's almost time for your next dose, skip the missed dose—do not double up
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Continue with your regular dosing schedule
Additional Notes:
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Not intended for short-term appetite loss
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Not a replacement for nutritional therapy or other cancer treatments
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Periodic blood tests and weight checks may be required during therapy
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May mask symptoms of underlying disease progression, so regular evaluations are essential
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Discuss fertility preservation with your doctor before starting if you plan to have children
