Product Introduction:
Bdsure 22.5mg is a depot injection formulation of Leuprolide Acetate, providing sustained hormone suppression over 6 months with a single dose. It is widely used in the treatment of prostate cancer, endometriosis, and uterine fibroids, as well as in precocious puberty in children. The extended dosing interval offers convenience for long-term therapy.
Bdsure 22.5mg is used to manage:
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Advanced Prostate Cancer – for long-term testosterone suppression
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Endometriosis – reduces estrogen levels to shrink endometrial tissue
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Uterine Fibroids – preoperative management or symptom control
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Central Precocious Puberty (CPP) – in children to delay premature sexual development
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Hormone-sensitive Breast Cancer – in premenopausal women (off-label or under specialist care)
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Assisted Reproductive Technology (ART) – in IVF protocols to control hormonal cycles
Storage Instructions:
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Store below 25°C (77°F)
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Do not freeze
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Protect from light and moisture
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Use immediately after reconstitution
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Keep out of reach of children
How It Works (Mechanism of Action):
Leuprolide Acetate is a GnRH agonist. Initially, it causes a surge in LH (luteinizing hormone) and FSH (follicle-stimulating hormone) levels. With continued use, it desensitizes the pituitary gland, reducing LH and FSH secretion, which in turn suppresses the production of testosterone in males and estrogen in females, slowing or stopping the progression of hormone-driven conditions.
Side Effects:
Common side effects:
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Hot flashes
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Sweating
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Headaches
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Decreased libido
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Fatigue
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Vaginal dryness (in women)
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Injection site pain or irritation
Serious side effects:
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Bone thinning or osteoporosis (with long-term use)
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Mood changes or depression
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Irregular heartbeat or QT prolongation
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High blood sugar or diabetes onset
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Tumor flare-up (initial hormonal surge in prostate cancer)
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Rare allergic reactions
Dosage (Typical Recommended Dose):
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22.5 mg intramuscular injection once every 6 months (24 weeks)
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Dosage and administration interval may vary based on indication and individual response
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Only to be administered by a trained healthcare professional
Method of Administration:
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Deep intramuscular injection in the gluteal region
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Reconstitute the powder with the provided diluent before administration
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Rotate injection sites with each dose
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Do not self-administer; professional administration is essential for effectiveness and safety
Precautions:
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Not to be used during pregnancy or breastfeeding – may cause harm to the fetus or infant
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Use non-hormonal contraception during treatment
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Caution in patients with osteoporosis, heart disease, or mental health disorders
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Periodic assessment of bone density, blood sugar, and mood symptoms is recommended
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May cause a temporary increase in symptoms during the first weeks of treatment (tumor flare)
Drug Interactions:
Potential interactions with:
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QT-prolonging drugs (e.g., certain antibiotics, antiarrhythmics)
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Steroids or medications affecting glucose metabolism
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Antidepressants or antipsychotics
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Other hormonal therapies or chemotherapy agents
Always inform your doctor about all medications and supplements you're taking.
Allergies:
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Contraindicated in patients allergic to Leuprolide, GnRH analogs, or any ingredient in the injection
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Symptoms may include rash, itching, swelling, dizziness, or breathing difficulty
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Discontinue and seek immediate medical attention if signs of allergic reaction occur
Overdose Information:
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Overdose is unlikely due to long-acting formulation and professional administration
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If accidental overdose occurs, monitor for excessive suppression symptoms (e.g., severe fatigue, mood changes, hormonal imbalance)
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Supportive care is the primary approach; no specific antidote available
Missed Dose Instructions:
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This is a scheduled depot injection—if a dose is missed, contact your healthcare provider as soon as possible
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Delays can result in hormone rebound and worsening of symptoms
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Maintain regular dosing every 24 weeks (6 months) for effectiveness
Additional Notes:
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Bone health supplementation (e.g., Calcium, Vitamin D) may be advised during long-term therapy
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Patients should carry a treatment card or medical ID indicating they are on hormone suppression therapy
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Notify your doctor of any planned surgery or dental procedures
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Treatment is typically long-term and requires close monitoring of hormone levels and disease progression
